12/13/2023 0 Comments Jmicrovision softwarestrict warning: Declaration of views_plugin_row::options_validate() should be compatible with views_plugin::options_validate(&$form, &$form_state) in /home4/moshika/public_html//sites/all/modules/views/plugins/views_plugin_row.inc on line 134.strict warning: Declaration of views_handler_filter_term_node_tid::value_validate() should be compatible with views_handler_filter::value_validate($form, &$form_state) in /home4/moshika/public_html//sites/all/modules/views/modules/taxonomy/views_handler_filter_term_node_tid.inc on line 302.strict warning: Declaration of views_handler_filter_boolean_operator::value_validate() should be compatible with views_handler_filter::value_validate($form, &$form_state) in /home4/moshika/public_html//sites/all/modules/views/handlers/views_handler_filter_boolean_operator.inc on line 159.strict warning: Declaration of views_handler_filter::options_submit() should be compatible with views_handler::options_submit($form, &$form_state) in /home4/moshika/public_html//sites/all/modules/views/handlers/views_handler_filter.inc on line 607.strict warning: Declaration of views_handler_filter::options_validate() should be compatible with views_handler::options_validate($form, &$form_state) in /home4/moshika/public_html//sites/all/modules/views/handlers/views_handler_filter.inc on line 607.strict warning: Declaration of views_handler_argument::init() should be compatible with views_handler::init(&$view, $options) in /home4/moshika/public_html//sites/all/modules/views/handlers/views_handler_argument.inc on line 744.strict warning: Non-static method view::load() should not be called statically in /home4/moshika/public_html//sites/all/modules/views/views.module on line 906.In conjunction with no obvious histopathological toxicity signs, decorin represents a promising substance to inhibit PVR reactions. In conclusion, in this rabbit model of PVR, adjuvant decorin application during vitrectomy effectively reduces fibrosis and TRD development. There were no drug-related toxic effects evident on clinical and histopathological examination. In decorin-treated eyes, vitrectomy outcome was best when preformed at 1 week after trauma. TRD was prevented in 13 rabbits out of 15 in GIII to 14 rabbits out of 15 in GIV. Depending on dosage and time of vitrectomy, PVR could be completely avoided (PVR score = 0) in 16 rabbits out of 30. The best results were obtained when surgery was used in conjunction with decorin that reduced both the PVR score and fibrosis development significantly (p < 0.05). Vitrectomy had a positive effect (p < 0.05) on PVR development when preformed immediately, however the developed fibrosis was high. The control group GI developed severe PVR with tractional retinal detachment (TRD) (PVR score ≥2) in four rabbits out of five. The amount of fibrosis was quantified using JMicroVision© software. GIII and GIV received 100 μg or 200 μg decorin, respectively. Groups (GII-GIV) consisted of subgroups receiving phacovitrectomy at three different time points (a) at the time of trauma, (b) 1 week following trauma, and (c) 2 weeks following trauma. One group (GI) reveals a control with no treatment after trauma. Traumatic PVR was induced in 50 rabbits divided into ten groups (n = 5). This study evaluates the effect of decorin, a naturally occurring TGF-ß inhibitor, in an experimental rabbit model for proliferative vitreoretinopathy (PVR). The cytokine transforming growth factor-ß (TGF-ß) is a pivotal contributor to tissue fibrosis and a key cytokine in the pathogenesis of cellular transdifferentiation, epithelial-mesenchymal transition (EMT), and cell adhesion.
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